Sarmento Bruno Chitosan-Based Systems for Biopharmaceuticals. Delivery, Targeting and Polymer Therapeutics

author Sarmento Bruno
isbn 9781119962960
17529.92 РУБ
Описание:

Topics covered include: chemical and technological advances in chitins and chitosans useful for the formulation of biopharmaceuticals physical properties of chitosan and derivatives in sol and gel states absorption promotion properties of chitosan and derivatives biocompatibility and biodegradation of chitosan and derivatives biological and pharmacological activity of chitosan and derivatives biological, biopharmaceuticals, biodegradable, and clinical application and potential. It is non-toxic, medicinal chemistry, Part IV presents diverse viewpoints on different issues such as regulatory, chemical and physical compatibility of chitosan and biopharmaceuticals approaches for functional modification or crosslinking of chitosan use of chitosan and derivatives in conventional biopharmaceutical dosage forms manufacture techniques of chitosan-based microparticles and nanoparticles for biopharmaceuticals chitosan and derivatives for biopharmaceutical use: mucoadhesive properties chitosan-based systems for mucosal delivery of biopharmaceuticals chitosan-based delivery systems for mucosal vaccination chitosan-based nanoparticulates for oral delivery of biopharmaceuticals chitosan-based systems for ocular delivery of biopharmaceuticals chemical modification of chitosan for delivery of DNA and siRNA target-specific chitosan-based nanoparticle systems for nucleic acid delivery functional PEGylated chitosan systems for biopharmaceuticals stimuli-sensitive chitosan-based systems for biopharmaceuticals chitosan copolymers for biopharmaceuticals application of chitosan for anti-cancer biopharmaceutical delivery chitosan-based biopharmaceuticals scaffolds in tissue engineering and regenerative medicine wound healing properties of chitosan and its use in wound dressing biopharmaceuticals toxicological properties of chitosan and derivatives for biopharmaceutical applications regulatory status of chitosan and derivatives patentability and intellectual property issues quality control and good manufacturing practice preclinical and clinical use of chitosan and derivatives for biopharmaceuticals Chitosan-Based Systems for Biopharmaceuticals is an important compendium of fundamental concepts, manufacturing and toxicological requirements of chitosan and its derivatives related to the development of biopharmaceutical products, practical tools and applications of chitosan-based biopharmaceuticals for researchers in academia and industry working in drug formulation and delivery, biocompatible, bioengineering and new materials development. Finally, and focuses on the synergistic effects between chitosan and this particular subset of pharmaceuticals. Part I discusses general aspects of chitosan and its derivatives, and acts as a bioadhesive with otherwise unstable biomolecules – making it a valuable component in the formulation of biopharmaceutical drugs.Chitosan is a linear polysaccharide commercially produced by the deacetylation of chitin. Part III discusses specific applications of chitosan and its derivatives for biopharmaceutical use. The book is divided in four different parts.. Chitosan-Based Systems for Biopharmaceuticals provides an extensive overview of the application of chitosan and its derivatives in the development and optimisation of biopharmaceuticals. Part II deals with the use of chitosan and derivatives in the formulation and delivery of biopharmaceuticals, as well as their patent status, pharmacy, with particular emphasis on issues related to the development of biopharmaceutical chitosan-based systems



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